Fillers And Blindness: Why Does It Happen?

by Dr Wan Chee Kwang
January 27, 2021

If you’ve done your research on fillers, you’ve probably come across rare but serious side effects like skin necrosis, scarring, and even more devastating, blindness. Yes, the odds of them happening are low (about 50 cases a year worldwide), but the risk is still there. In a recent literature review on the implications of filler injections, out of 98 cases of visual impairment, 65 had unilateral vision loss and only 2 cases were reversible. 

In July 2023, a woman in Singapore experienced a rare but serious complication after receiving a dermal filler treatment at a clinic in Redhill. This is the first reported case of its kind in Singapore. The woman lost her vision due to an accidental injection of the filler into her bloodstream, leading to a blood vessel occlusion (or blockage) during the procedure. The woman was injected with AestheFill, a dermal filler from South Korea that temporarily reduces wrinkles and folds in the skin. This product was registered for use in Singapore in October 2021. The Health Sciences Authority (HSA) and the Ministry of Health (MOH) are investigating the case.

This indeed sounds very frightening. Don’t worry, I’m not here to scare you against getting fillers; in fact it’s the opposite of what I’m trying to do. In this article, I will explain the mechanics of how fillers can cause blindness and how to reduce your risk.

Understanding the different types of fillers

In today’s age, patients get to choose from a plethora of dermal fillers for facial aesthetic correction. These fillers range from hyaluronic acid, calcium hydroxylapatite, polycaprolactone to autologous fat. Of these, hyaluronic acid is the most widely used due to its enviable water-attracting properties and longevity. At my clinic, I use both hyaluronic acid-based and collagen-stimulating fillers. I rarely see autologous fat injections offered in most aesthetic clinics in Singapore; but if you’re curious, fat injections basically use fat harvested from the patient’s own body to enhance facial fullness or fill creases. Autologous fat filler procedures are more extensive than ready-made soft-tissue fillers as fat must first be drafted off.

How can dermal fillers induce blindness?

We have very small blood vessels or arteries surrounding our forehead and eye area. These blood vessels supply blood to the area. Blindness due to blood vessel blockage is a known risk for dermal fillers. When fillers are not injected properly, this can lead to a blockage of a blood vessel that supplies blood to the eye, resulting in blindness. This condition is also known as central retinal artery occlusion. 

It’s thought that there are a few factors that contribute to blindness.

Site of injection
Researchers have found that injection sites that hold the highest risk are the glabellar (38.8%), nasal region (25.5%), nasolabial fold (13.3%), and the forehead (12.2%). The glabellar region has the highest risk because any deep injection on the periosteum stands a chance of entering the supratrochlear artery and supraorbital artery, whereas the nasal dorsum and nasolabial folds are nearer the facial artery and angular artery. 

Type of filler
So far, about 47% of cases of filler-induced blindness are attributed to autologous fat injections. The rest of the cases go to different soft-tissue fillers. This is thought to be because of the variation in the size of the fat globules, which can differ in size. Variation in size affects the blockage of small, medium and large-sized arteries. Since regular soft-tissue fillers have smaller particles that are more constant in size, they will therefore potentially only block certain smaller-sized arteries. Even if these arteries are blocked, they may still be able to deliver blood with oxygen to the eye and so the prognosis may not be as bad.

Filler injection

Speed and pressure of injection
To any doctor, his most important body part is probably his hands because the hands are what hold and control the instrument. When it comes to injecting a filler, it’s been deduced in the literature that the speed and pressure of the injection have an influence on the flow of the filler into the vessel. In many cases of retinal necrosis, it was found that the filler was injected with too much pressure.

How do I avoid blindness caused by fillers?

1. Avoid the arteries
This may seem obvious, but all clinicians providing filler injections should possess an in-depth and working knowledge of facial and vascular anatomy. Do extensive research on the doctor you’re considering — do they have the necessary qualifications? Do they have an excellent track record of clinical practice?

2. Inject to the correct depth and plane
Blood vessels run at different depth and planes depending on which part of the face is being treated. Awareness and precise control of the location of the needle tip and hence the injection is critical to avoid injecting into or near the facial arteries.

3. Have a crisis strategy in place
No procedure is completely immune to error. Blindness from fillers is very rare, but should central retinal artery occlusion take place, patients only have a retinal survival time of 60-90 minutes. Rapid intervention is required and during this limited window, you must be referred immediately to an ophthalmologist for further treatment.


With all that’s said, I hope you understand that every procedure comes with its risks; but they can be reduced with a responsible and competent doctor. Ultimately, it’s the doctor’s responsibility to ensure that every procedure goes smoothly.

While this incident is concerning, it is a rare complication. Measures can be taken to prevent similar incidents in the future. As always, patient safety remains our utmost priority. Remember, when considering any aesthetic treatment, it’s important to do your research, understand the risks, and choose a qualified medical practitioner. Your health and safety should always come first.

Stay safe and informed!


  1. Beleznay, K., Carruthers, J. D., Humphrey, S., & Jones, D. (2015). Avoiding and Treating Blindness From Fillers: A Review of the World Literature. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]41(10), 1097–1117.
  2. Chatrath, V., Banerjee, P. S., Goodman, G. J., & Rahman, E. (2019). Soft-tissue Filler-associated Blindness: A Systematic Review of Case Reports and Case Series. Plastic and reconstructive surgery. Global open7(4), e2173.

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